If Liverpool City Council's bid is successful, it would bring 700 artistic gymnasts from more than 80 nations to British shores, providing an estimated £6 million boost to local economy.
The championships last came to the UK in 2015 when Max Whitlock won his first pommel horse world title at Glasgow’s SSE Hydro, with the event watched by a worldwide audience of 665 million viewers.
Should Liverpool win the bid, it would be the city's biggest ever international sporting event held at the Echo Arena complex, which has hosted the British Gymnastics Championships since 2012 and will stage the BBC Sport Personality of the Year awards on Sunday.
And for Tweddle, who won Olympic bronze on the uneven bars at London 2012, believes the city would do world gymnastics proud should the sport come to Merseyside.
"I lived, trained and went to university in Liverpool and, having won three world titles, it fills me with a huge amount of excitement and great pride to imagine these championships in our great city in 2022," she said.
"The tournament would be ideal for gymnasts given the compact nature of all the venues and hotels and having competed myself at the Echo Arena, I know full well what an amazing atmosphere our passionate fans can bring to the event."
Joe Anderson, Mayor of Liverpool, added; "The World Gymnastics Championships in 2022 would be a huge sporting occasion for Liverpool and a unique opportunity to showcase the city to a global audience.
"Liverpool has a fantastic track record in nurturing gymnastic talent like triple world champion Beth Tweddle and we've fostered a great relationship with British Gymnastics by hosting its championships since 2012.
"A lot of hard work remains to be done but our exciting bid for the 2022 Commonwealth Games undoubtedly boosted the city's reputation for its ability to host prestigious sporting events."